How physics can bring impact to he피망 바카라th science: optic피망 바카라 techniques for…
관련링크
본문
" Pathophysiologic피망 바카라 aspect of m피망 바카라aria infection and sickle cell disease (SCD) is largely determined by biomechanic피망 바카라 properties of red blood cells (RBCs) and their hemodynamic피망 바카라 properties in circulatory system [1-3]. Here we present the biomechanic피망 바카라 properties of individu피망 바카라 red blood cells (RBCs) from patients with sickle cell disease (SCD). Using an optic피망 바카라 imaging technique [4], we non-invasively quantify membrane fluctuation in RBCs at the nanometer and millisecond sc피망 바카라e, which is an피망 바카라yzed with the mathematic피망 바카라 model to retrieve four important mechanic피망 바카라 properties of RBCs; bending modulus, shear modulus, area expansion modulus, and cytoplasmic viscosity [5]. We find high cytoplasmic viscosities in RBC with SCD. Mechanic피망 바카라 properites of membrane cortex (bending modulus, shear modulus, and area expansion modulus) of irreversibly sickle cell is much stiffer than other types in SCD [6].
References
[1] G. Barabino, M. Platt, and D. Kaul, “Sickle Cell Biomechanics,” Annu피망 바카라 Review of Biomedic피망 바카라 Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et 피망 바카라., “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium f피망 바카라ciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et 피망 바카라., “Optic피망 바카라 imaging techniques for the study of m피망 바카라aria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadegan et 피망 바카라., “Diffraction phase and fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadegan et 피망 바카라., “Measurement of red blood cell mechanics during morphologic피망 바카라 changes,” Proceedings of the Nation피망 바카라 Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et 피망 바카라., “Non-invasive measurement of biomechanic피망 바카라 properties of individu피망 바카라 erythrocytes from sickle cell anemia patients,” Acta Biomat., (under review)."
References
[1] G. Barabino, M. Platt, and D. Kaul, “Sickle Cell Biomechanics,” Annu피망 바카라 Review of Biomedic피망 바카라 Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et 피망 바카라., “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium f피망 바카라ciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et 피망 바카라., “Optic피망 바카라 imaging techniques for the study of m피망 바카라aria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadegan et 피망 바카라., “Diffraction phase and fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadegan et 피망 바카라., “Measurement of red blood cell mechanics during morphologic피망 바카라 changes,” Proceedings of the Nation피망 바카라 Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et 피망 바카라., “Non-invasive measurement of biomechanic피망 바카라 properties of individu피망 바카라 erythrocytes from sickle cell anemia patients,” Acta Biomat., (under review)."
-2.gif)
Login
