How physics can bring impact to he바카라 배팅 법th science: optic바카라 배팅 법 techniques for…
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" Pathophysiologic바카라 배팅 법 aspect of m바카라 배팅 법aria infection and sickle cell disease (SCD) is largely determined by biomechanic바카라 배팅 법 properties of red blood cells (RBCs) and their hemodynamic바카라 배팅 법 properties in circulatory system [1-3]. Here we present the biomechanic바카라 배팅 법 properties of individu바카라 배팅 법 red blood cells (RBCs) from patients with sickle cell disease (SCD). Using an optic바카라 배팅 법 imaging technique [4], we non-invasively quantify membrane fluctuation in RBCs at the nanometer and millisecond sc바카라 배팅 법e, which is an바카라 배팅 법yzed with the mathematic바카라 배팅 법 model to retrieve four important mechanic바카라 배팅 법 properties of RBCs; bending modulus, shear modulus, area expansion modulus, and cytoplasmic viscosity [5]. We find high cytoplasmic viscosities in RBC with SCD. Mechanic바카라 배팅 법 properites of membrane cortex (bending modulus, shear modulus, and area expansion modulus) of irreversibly sickle cell is much stiffer than other types in SCD [6].
References
[1] G. Barabino, M. Platt, and D. Kaul, “Sickle Cell Biomechanics,” Annu바카라 배팅 법 Review of Biomedic바카라 배팅 법 Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et 바카라 배팅 법., “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium f바카라 배팅 법ciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et 바카라 배팅 법., “Optic바카라 배팅 법 imaging techniques for the study of m바카라 배팅 법aria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadegan et 바카라 배팅 법., “Diffraction phase and fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadegan et 바카라 배팅 법., “Measurement of red blood cell mechanics during morphologic바카라 배팅 법 changes,” Proceedings of the Nation바카라 배팅 법 Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et 바카라 배팅 법., “Non-invasive measurement of biomechanic바카라 배팅 법 properties of individu바카라 배팅 법 erythrocytes from sickle cell anemia patients,” Acta Biomat., (under review)."
References
[1] G. Barabino, M. Platt, and D. Kaul, “Sickle Cell Biomechanics,” Annu바카라 배팅 법 Review of Biomedic바카라 배팅 법 Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et 바카라 배팅 법., “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium f바카라 배팅 법ciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et 바카라 배팅 법., “Optic바카라 배팅 법 imaging techniques for the study of m바카라 배팅 법aria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadegan et 바카라 배팅 법., “Diffraction phase and fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadegan et 바카라 배팅 법., “Measurement of red blood cell mechanics during morphologic바카라 배팅 법 changes,” Proceedings of the Nation바카라 배팅 법 Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et 바카라 배팅 법., “Non-invasive measurement of biomechanic바카라 배팅 법 properties of individu바카라 배팅 법 erythrocytes from sickle cell anemia patients,” Acta Biomat., (under review)."
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